Depression is believed to be caused by chemical imbalances in the brain. A deficiency of two key chemicals in particular — norepinephrine and serotonin — theoretically contributes to depressed mood, poor sleep, anxiety, weight loss, and other symptoms of depression.

The mechanism of action of all antidepressants is not clearly understood. REMERON® is thought to correct the chemical imbalance in a different way, by increasing the release of both norepinephrine and serotonin from nerve cells in the brain. Increased serotonergic activity at the 5-HT-1 receptor site is believed to relieve the symptoms of depression.

In addition, REMERON® blocks two other serotonin receptor sites. Stimulation of these receptor sites may result in the more commonly seen serotonergic — "nuisance" — side effects such as insomnia, nervousness, nausea, and loss of sexual drive.

While this sheet contains important information, it does not list all the benefits and risks of

Answers to the 10 most-asked questions about REMERON®

"How do I take REMERON®?"

Your doctor will tell you exactly how to take your medication. Most likely your doctor will tell you to take REMERON® once every day at bedtime. (Never increase your dose or stop taking this medication without first talking to your doctor.)

"What if I forget a dose?"

Call your doctor for specific instructions.

"When will I feel better?"

As with most antidepressants, relief of the symptoms of depression may take 4 to 6 weeks or longer. With REMERON®, some symptoms associated with depression, such as anxiety and loss of sleep, may improve in as little as 1 to 2 weeks. Full antidepressant effect can take longer. Your doctor will check your progress and, based on how you are feeling, will tell you if treatment beyond 6 weeks is needed.

Every patient reacts to therapy in a slightly different way. It is not possible to predict who might benefit from antidepressant therapy with REMERON®. Successful therapy begins by taking your medication the way your doctor has instructed.

"What about ‘side effects,’ and what do I do about them?"

All medications have the potential to cause side effects. The most common side effects with REMERON® are drowsiness, increased appetite, weight gain, and dizziness. Be assured that not everyone taking REMERON® will have side effects. If you feel that you are experiencing any side effects, talk to your doctor, who may change your dose of REMERON® or make another change.

Flu-like symptoms such as sore throat, fever, chills, weakness, muscle aches, or mouth sores may be warning signs of a very rare, but serious, blood disorder that reduces white blood cells which are used to fight infection. While there’s only a small risk of developing this disorder, it can be harmful if not treated immediately. Call your doctor if you experience any of these symptoms.

Although it is unlikely to occur, notify your doctor immediately if you experience an allergic reaction while taking this medication. Symptoms include difficulty in breathing, skin rash, hives, or itching.

"Could this drug affect my sex life?"

Because of the way it works, REMERON® is not likely to cause sexual problems. However, if they occur, be sure to discuss them with your doctor.

"Can I drive while I’m taking REMERON®?"

Remember that when you first start taking REMERON®, you may feel drowsy. This drowsiness may affect your ability to drive, use machines, or do tasks that require you to be alert. Be careful with these types of activities until you are certain that REMERON® does not affect your ability to participate.

"Can I drink alcohol?"

As with any drug for depression, you should avoid alcoholic beverages. REMERON® can affect your motor skills and your ability to think clearly, and these effects get worse when you use alcohol while taking REMERON®.

"Should I avoid other drugs?"

As with other antidepressants, if you have been taking an MAOI (monoamine oxidase inhibitor), you should wait at least 14 days after you stop taking the MAOI before you start taking REMERON®.

Since all antidepressants can interact with other medications, be sure to tell your doctor if you are taking, or plan to take, any prescription or over-the-counter medications.

"How long do I take REMERON®?"

Although you may notice that you begin to feel better within 1 to 2 weeks after starting REMERON®, the full antidepressant effect can take longer. Never stop taking your medication without first speaking with your doctor.

"What about pregnancy?"

If you are pregnant, plan to become pregnant, or are breastfeeding, let your doctor know before you start taking your medication. Your doctor can decide if REMERON® is the right therapy for you.

Be sure to follow your doctor’s instructions: