Fosamax (generic name, alendronate) belongs to a group of drugs called bisphosphonates and is commonly used to prevent and treat osteoporosis in post-menopausal women. Fosamax has been shown to strengthen bones and reduce hip and spinal fractures. Studies show that after three years of use, Fosamax can reduce the risk of hip fractures in patients with a history of vertebral fracture by 51%. Recent research shows that Fosamax may be combined with hormone replacement therapy (HRT), and in fact, when used in combination, patients may receive increased protection from fractures. However, the long-term use of combination Fosamax and HRT has not been assessed.
Side Effects
Side effects of Fosamax may include:
- abdominal pain
- nausea
- indigestion
- constipation and diarrhea
- muscle or joint pain
- headache
In addition, some patients who take Fosamax develop severe digestive reactions including irritation, inflammation or ulceration of the esophagus. These reactions can cause chest pain, heartburn or difficulty or pain upon swallowing. The risk of severe esophageal adverse reactions appears to be greater in patients who lie down immediately after taking Fosamax and/or those who fail to take Fosamax with a full glass of water. Patients should not take Fosamax if they have certain disorders of the esophagus, they cannot stand or sit upright for at least 30 minutes, they have low levels of calcium in their blood, or they have severe kidney disease. Fosamax is available in once daily or once weekly regimens.
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