Common uses
This medicine is an estrogen and progesterone combination used to treat the symptoms of menopause. It may also be used to treat certain menstrual disorders, osteoporosis, or other conditions as determined by your doctor. Alternative medicines to prevent bone loss (osteoporosis) include raloxifene and bisphosphonate drugs such as alendronate.

Before using
WARNING: Two-drug combination hormone replacement therapy (estrogen and progestin menopause HRT) can infrequently cause breast cancer, heart disease (CHD/MI), stroke, or blood clots in the lung (PE), if used for a long period of time (greater than one year). Therefore, the risks of use of HRT for a long period of time (more than one year) must be discussed with your doctor. Use of two-drug HRT for short periods of time (less than one year) to relieve menopause symptoms may be considered. Discuss risks and benefits with your doctor. Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking rifampin. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a history of cancer or pulmonary embolism. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.

Directions
Follow the directions for using this medicine provided by your doctor. This medicine may come with a patient information leaflet. Ask your doctor, nurse, or pharmacist any questions you may have about this medicine. This medicine may be taken on an empty stomach or with food. TAKE THIS MEDICINE at the same time every day with no more than 24 hours between doses. STORE THIS MEDICINE at room temperature below 77 degrees F (25 degrees C), away from heat and light. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Cautions
YOU MAY EXPERIENCE absence of menstrual periods while using this medicine. If you experience irregular menstrual periods, contact your doctor. YOU SHOULD PERFORM regular self-examinations of your breasts. If you have questions about how to do this, ask your doctor, nurse, or pharmacist. SMOKING WHILE USING THIS MEDICINE may increase your risk of stroke, heart attack, blood clots, high blood pressure, or other diseases of the heart and blood vessels. IF YOU WEAR CONTACT LENSES and you develop problems with them, contact your doctor. THIS MEDICINE MAY CAUSE dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths. DO NOT USE THIS MEDICINE if you are pregnant. IF YOU SUSPECT THAT YOU COULD BE PREGNANT, contact your doctor immediately. THIS MEDICINE IS EXCRETED IN BREAST MILK. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. IF YOU HAVE DIABETES, this medicine may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

Possible side effects
SIDE EFFECTS that may go away during treatment, include dizziness, lightheadedness, nausea, stomach upset, or bloating. If they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR AS SOON AS POSSIBLE if you experience severe depression; breast tenderness; breakthrough bleeding, spotting, or change in menstrual periods; weight change; swelling of your fingers or ankles; or changes in vision. CONTACT YOUR DOCTOR IMMEDIATELY if you experience calf/leg pain or swelling; trouble breathing or shortness of breath; chest pain; one-sided weakness; slurred speech; lumps in the breast; sudden severe headache, dizziness, or fainting; yellowing of the skin or eyes; dark urine; or abdominal pain, swelling, or tenderness; vomiting; or coughing up blood. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.

Drug interactions
Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other.

If you take too much
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea and vomiting.

Additional information
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain refills before your supply runs